One of these things just doesn't belong

Group 1:

Roger Ward – Young Einstein (1988)
André René Roussimoff – The Princess Bride (1987)
James George Janos – Predator (1987)
Terry Bollea – Rocky III (1982)
Laurence Tureaud – D.C. Cab (1983)

All actors are former wrestlers. Of these, only Andre "the Giant" Roussimoff has been featured on a Dead Wrestler Trading Card
***

Group 2:

Cool World (1992)
Who Framed Roger Rabbit (1988)
The Incredible Mr. Limpet (1964)
Kill Bill, Vol 1 (2003)
Space Jam (1996)

All films feature a combination of live-action and animation. Only in Kill Bill, Volume 1 do these two media fail to interact.
***

Group 3:

Gone in Sixty Seconds (2000)
The Thomas Crown Affair (1999)
Dirty Rotten Scoundrels (1988)
I Am Legend (2007)
Never Say Never Again (1983)

All films are remakes of previous films:
Gone in 60 Seconds (1974)
The Thomas Crown Affair (1968)
Bedtime Story (1964)
The Omega Man (1971)
Thunderball (1965)

Only The Thomas Crown Affair retained the same title in both films
***

Group 4:

Mad Max (1979)
Yojimbo (1961)
Fistful of Dollars (Per un pugno di dollari) (1964)
Old Boy (2003)
Wild at Heart (1989)

All five films feature a severed human hand. Only Old Boy fails to have this severed hand interact with a dog.

The bonus bonus? I've never seen D.C. Cab, Space Jam, or I Am Legend.